Article

Inhibition of mitochondrial protein import and proteostasis by a pro-apoptotic lipid

2023-11-07

Abstract excerpt

Mitochondria-mediated cell death is critically regulated by bioactive lipids derived from sphingolipid metabolism. The lipid aldehyde trans-2-hexadecenal (t-2-hex) induces mitochondrial dysfunction from yeast to humans. Here we apply unbiased transcriptomic, functional genomics and chemoproteomic approaches in the yeast model to uncover the principal mechanisms and biological targets underlying this lipid-induced...

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Literature Corpus work: c1a4b2d2-ec9c-5259-bf7b-babd16ceec51
DOI: 10.1101/2023.11.06.565743

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