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Article

Preventing excessive autophagy protects from the pathology of mtDNA mutations in Drosophila melanogaster.

Nature communications - 23 Dec 2024

El Fissi Najla, Rosenberger Florian A, Chang Kai, Wilhalm Alissa, Barton-Owen Tom, Hansen Fynn M, Golder Zoe, Alsina David, Wedell Anna, Mann Matthias, Chinnery Patrick F, Freyer Christoph, Wredenberg Anna

Abstract excerpt

Aberration of mitochondrial function is a shared feature of many human pathologies, characterised by changes in metabolic flux, cellular energetics, morphology, composition, and dynamics of the mitochondrial network. While some of these changes serve as compensatory mechanisms to maintain cellular homeostasis, their chronic activation can permanently affect cellular metabolism and signalling, ultimately impairing...

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Identifiers

PMID: 39715749
DOI: 10.1038/s41467-024-55559-2
PMCID: PMC11666730

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