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Article

High-Dimensional Phenotyping Identifies Age-Emergent Cells in Human Mammary Epithelia

1 Apr 2018

Abstract excerpt

Aging is associated with tissue-level changes in cellular composition that are correlated with increased susceptibility to disease. Aging human mammary tissue shows skewed progenitor cell potency, resulting in diminished tumor-suppressive cell types and the accumulation of defective epithelial progenitors. Quantitative characterization of these age-emergent human cell subpopulations is lacking, impeding our...

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PMID: 29694896
DOI: 10.1016/j.celrep.2018.03.114

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