Article

Synaptic and Gene Regulatory Mechanisms in Schizophrenia, Autism, and 22q11.2 CNV Mediated Risk for Neuropsychiatric Disorders

2019-02-20

Abstract excerpt

<h4>Background</h4> 22q11.2 copy number variants (CNVs) are among the most highly penetrant genetic risk variants for developmental neuropsychiatric disorders such as schizophrenia (SCZ) and autism spectrum disorder (ASD). However, the specific mechanisms through which they confer risk remain unclear. <h4>Methods</h4> Using a functional genomics approach, we integrated transcriptomic data from the developing hum...

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Literature Corpus work: 6c75c076-69c5-5b0a-ba52-fa11dab5d0e2
DOI: 10.1101/555490

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