Article

Shared molecular neuropathology across major psychiatric disorders parallels polygenic overlap

2016-02-18

Abstract excerpt

Recent large-scale studies have identified multiple genetic risk factors for mental illness and indicate a complex, polygenic, and pleiotropic genetic architecture for neuropsychiatric disease. However, little is known about how genetic variants yield brain dysfunction or pathology. We use transcriptomic profiling as an unbiased, quantitative readout of molecular phenotypes across 5 major psychiatric disorders, in...

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Literature Corpus work: e23d66e3-e97a-510a-8d8e-9ce430329b7a
DOI: 10.1101/040022

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