Article

The 22q11.2 region regulates presynaptic gene-products linked to schizophrenia

2021-09-22

Abstract excerpt

To study how the 22q11.2 deletion predisposes to psychiatric disease, we generated induced pluripotent stem cells from deletion carriers and controls, as well as utilized CRISPR/Cas9 to introduce the heterozygous deletion into a control cell line. Upon differentiation into neural progenitor cells, we found the deletion acted in trans to alter the abundance of transcripts associated with risk for neurodevelopmental...

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Literature Corpus work: 50daa5ce-3c0f-5063-9cb5-c6d097eb6e8b
DOI: 10.1101/2021.09.22.461360

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