Article

Oligodendrocytes in human iPS cell-derived cortical grafts remyelinate adult rat and human cortical neurons

2023-03-25

Abstract excerpt

<h4>SUMMARY</h4> Neuronal loss and axonal demyelination underlie long-term functional impairments in patients affected by brain disorders such as ischemic stroke. Stem cell-based approaches reconstructing and remyelinating brain neural circuitry, leading to recovery, are highly warranted. Here we demonstrate the in vitro and in vivo production of myelinating oligodendrocytes from a human induced pluripotent ste...

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Literature Corpus work: 80683405-f089-532d-9c32-acb750d7d4bc
DOI: 10.1101/2023.03.24.534133

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