Article

D936Y and Other Mutations in the Fusion Core of the SARS-Cov-2 Spike Protein Heptad Repeat 1 Undermine the Post-Fusion Assembly

2020-06-09

Abstract excerpt

The iconic “red crown” of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is made of its spike (S) glycoprotein. The S protein is the Trojan horse of coronaviruses, mediating their entry into the host cells. While SARS-CoV-2 was becoming a global threat, scientists have been accumulating data on the virus at an impressive pace, both in terms of genomic sequences and of three-dimensional structures...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: c1732cdc-2271-5a44-a45c-e1933e226e58
DOI: 10.1101/2020.06.08.140152

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

D936Y and Other Mutations in the Fusion Core of the SARS-Cov-2 Spike Protein Heptad Repeat 1 Undermine the Post-Fusion AssemblyDOI 10.1101/2020.06.08.140152Read

D936Y and Other Mutations in the Fusion Core of the SARS-CoV-2 Spike Protein Heptad Repeat 1: Frequency, Geographical Distribution, and Structural EffectSemantic proximity Read

SARS-CoV-2 Omicron Variant Spike Glycoprotein Mutation Q954H Enhances Fusion Core Stability.Semantic proximity Read

Structural Ramifications of Spike Protein D614G Mutation in SARS-CoV-2Semantic proximity Read

Integrative structural studies of the SARS-CoV-2 spike protein during the fusion process (2022)Semantic proximity Read

Stabilizing the Closed SARS-CoV-2 Spike TrimerSemantic proximity Read

Mutations in the B.1.1.7 SARS-CoV-2 spike protein reduce receptor-binding affinity and induce a flexible link to the fusion peptideSemantic proximity Read

Stabilizing the closed SARS-CoV-2 spike trimer.Semantic proximity Read

Structural effects of spike protein D614G mutation in SARS-CoV-2.Semantic proximity Read

Structural conservation among variants of the SARS-CoV-2 spike postfusion bundleSemantic proximity Read

Interaction between heptad repeat 1 and 2 regions in spike protein of SARS-associated coronavirus: implications for virus fusogenic mechanism and identification of fusion inhibitorsSemantic proximity Read

Effect of SARS-CoV-2 spike mutations on its activation by TMPRSS2 and TMPRSS13Semantic proximity Read

Targeting an evolutionarily conserved “E-L-L” motif in the spike protein to develop a small molecule fusion inhibitor against SARS-CoV-2Semantic proximity Read