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Structural conservation among variants of the SARS-CoV-2 spike postfusion bundle

1 Apr 2022

Abstract excerpt

Variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) challenge currently available COVID-19 vaccines and monoclonal antibody therapies due to structural and dynamic changes of the viral spike glycoprotein (S). The heptad repeat 1 (HR1) and heptad repeat 2 (HR2) domains of S drive virus–host membrane fusion by assembly into a six-helix bundle, resulting in delivery of viral RNA into the host...

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PMID: 35363556
DOI: 10.1073/pnas.2119467119

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