Article

Pervasive selection against microRNA target sites in human populations

2018-09-18

Abstract excerpt

<h4>ABSTRACT</h4> MicroRNA target sites are often conserved during evolution and purifying selection to maintain such sites is expected. On the other hand, comparative analyses identified a paucity of microRNA target sites in co-expressed transcripts, and novel target sites can potentially be deleterious. We proposed that selection against novel target sites pervasive. The analysis of derived allele frequencies r...

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Literature Corpus work: c168df24-a038-553c-8326-8f0d8570c64f
DOI: 10.1101/420646

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