Article
Evidence for positive selection on a number of MicroRNA regulatory interactions during recent human evolution.
PLoS genetics - 1 Jan 2012
Li Jingjing, Liu Yu, Xin Xiaofeng, Kim Taehyung Simon, Cabeza Eduardo Aguiar, Ren Jie, Nielsen Rasmus, Wrana Jeffrey L, Zhang Zhaolei
Abstract excerpt
MicroRNA (miRNA)-mediated gene regulation is of critical functional importance in animals and is thought to be largely constrained during evolution. However, little is known regarding evolutionary changes of the miRNA network and their role in human evolution. Here we show that a number of miRNA binding sites display high levels of population differentiation in humans and thus are likely targets of local...
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