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Article

Pervasive Selection against MicroRNA Target Sites in Human Populations.

Molecular biology and evolution - 16 Dec 2020

Hatlen Andrea, Marco Antonio

Abstract excerpt

MicroRNA target sites are often conserved during evolution and purifying selection to maintain such sites is expected. On the other hand, comparative analyses identified a paucity of microRNA target sites in coexpressed transcripts, and novel target sites can potentially be deleterious. We proposed that selection against novel target sites pervasive. The analysis of derived allele frequencies revealed that, when...

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Identifiers

PMID: 32585012
DOI: 10.1093/molbev/msaa155
PMCID: PMC7743725

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