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Article

Signatures of purifying and local positive selection in human miRNAs.

American journal of human genetics - 1 Mar 2009

Quach Hélène, Barreiro Luis B, Laval Guillaume, Zidane Nora, Patin Etienne, Kidd Kenneth K, Kidd Judith R, Bouchier Christiane, Veuille Michel, Antoniewski Christophe, Quintana-Murci Lluís

Abstract excerpt

MicroRNAs (miRNAs) are noncoding RNAs involved in posttranscriptional gene repression, and their role in diverse physiological processes is increasingly recognized. Yet, few efforts have been devoted to evolutionary studies of human miRNAs. Knowledge about the way in which natural selection has targeted miRNAs should provide insight into their functional relevance as well as their mechanisms of action. Here we...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 19232555
DOI: 10.1016/j.ajhg.2009.01.022
PMCID: PMC2667980

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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