Article
Human polymorphism at microRNAs and microRNA target sites.
Proceedings of the National Academy of Sciences of the United States of America - 27 Feb 2007
Saunders Matthew A, Liang Han, Li Wen-Hsiung
Abstract excerpt
MicroRNAs (miRNAs) function as endogenous translational repressors of protein-coding genes in animals by binding to target sites in the 3' UTRs of mRNAs. Because a single nucleotide change in the sequence of a target site can affect miRNA regulation, naturally occurring SNPs in target sites are candidates for functional variation that may be of interest for biomedical applications and evolutionary studies....
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