Article
DNA methylome analysis identifies accelerated epigenetic ageing associated with postmenopausal breast cancer susceptibility.
European journal of cancer (Oxford, England : 1990) - 1 Apr 2017
Ambatipudi Srikant, Horvath Steve, Perrier Flavie, Cuenin Cyrille, Hernandez-Vargas Hector, Le Calvez-Kelm Florence, Durand Geoffroy, Byrnes Graham, Ferrari Pietro, Bouaoun Liacine, Sklias Athena, Chajes Véronique, Overvad Kim, Severi Gianluca, Baglietto Laura, Clavel-Chapelon Françoise, Kaaks Rudolf, Barrdahl Myrto, Boeing Heiner, Trichopoulou Antonia, Lagiou Pagona, Naska Androniki, Masala Giovanna, Agnoli Claudia, Polidoro Silvia, Tumino Rosario, Panico Salvatore, Dollé Martijn, Peeters Petra H M, Onland-Moret N Charlotte, Sandanger Torkjel M, Nøst Therese H, Weiderpass Elisabete, Quirós J Ramón, Agudo Antonio, Rodriguez-Barranco Miguel, Huerta Castaño José María, Barricarte Aurelio, Fernández Ander Matheu, Travis Ruth C, Vineis Paolo, Muller David C, Riboli Elio, Gunter Marc, Romieu Isabelle, Herceg Zdenko
Abstract excerpt
AIM OF THE STUDY: A vast majority of human malignancies are associated with ageing, and age is a strong predictor of cancer risk. Recently, DNA methylation-based marker of ageing, known as 'epigenetic clock', has been linked with cancer risk factors. This study aimed to evaluate whether the epigenetic clock is associated with breast cancer risk susceptibility and to identify potential epigenetics-based biomarkers...
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