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Article

Human aging DNA methylation signatures are conserved but accelerated in cultured fibroblasts

3 Jun 2019

Abstract excerpt

Aging is associated with progressive and site-specific changes in DNA methylation (DNAm). These global changes are captured by DNAm clocks that accurately predict chronological age in humans but relatively little is known about how clocks perform in vitro. Here we culture primary human fibroblasts across the cellular lifespan (~6 months) and use four different DNAm clocks to show that age-related DNAm signatures...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 31156022
DOI: 10.1080/15592294.2019.1626651

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