Article

Dual Inhibition of CDK4/6 and mTORC1 Establishes a Preclinical Strategy for Translocation Renal Cell Carcinoma

2025-07-17

Abstract excerpt

<h4>Purpose</h4> Translocation renal cell carcinoma (tRCC) is a rare and aggressive subtype of kidney cancer driven by an oncogenic fusion involving a transcription factor in the MiT/TFE gene family, most commonly TFE3 . Treatment of tRCC currently lacks a clear standard of care, underscoring the pressing need to nominate new therapeutic targets with mechanistic rationale in this cancer. <h4>Experimental Desig...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: c1517236-7d2e-58a0-8a93-ee5f41ddc5cd
DOI: 10.1101/2025.07.11.663903

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Dual Inhibition of CDK4/6 and mTORC1 Establishes a Preclinical Strategy for Translocation Renal Cell CarcinomaDOI 10.1101/2025.07.11.663903Read

Therapeutic Targeting of TFE3/IRS-1/PI3K/mTOR Axis in Translocation Renal Cell CarcinomaSemantic proximity Read

Integrative Clinical and Molecular Characterization of Translocation Renal Cell CarcinomaSemantic proximity Read

Proteogenomic characterization of MiT family translocation renal cell carcinomaSemantic proximity Read

MiTF/TFE Translocation Renal Cell Carcinomas: From Clinical Entities to Molecular InsightsSemantic proximity Read

NDC80 status pinpoints mitotic kinase inhibitors as emerging therapeutic options in clear cell renal cell carcinomaSemantic proximity Read

Phenotypical screening on metastatic PRCC-TFE3 fusion translocation renal cell carcinoma organoids reveals potential therapeutic agentsSemantic proximity Read

Next-generation sequencing of translocation renal cell carcinoma reveals novel RNA splicing partners and frequent mutations of chromatin-remodeling genes.Semantic proximity Read

Deciphering mitotic catastrophe–associated transcriptomic patterns to predict prognosis and immunotherapy response in renal cell carcinomaSemantic proximity Read

Management of translocation carcinomas of the kidneySemantic proximity Read

Translocation Renal Cell Carcinoma: An Update on Clinicopathological and Molecular FeaturesSemantic proximity Read

Comprehensive molecular characterization of TFE3-rearranged renal cell carcinoma.Semantic proximity Read

An engineered tumor organoid model reveals cellular identity and signaling trajectories underlying translocation RCCSemantic proximity Read