Article

An engineered tumor organoid model reveals cellular identity and signaling trajectories underlying translocation RCC

2023-09-05

Abstract excerpt

Translocation renal cell carcinoma (tRCC) is a rare, aggressive type of kidney cancer primarily occurring in children. They are genetically defined by translocations involving MiT/TFE gene family members, TFE3 or, in rare cases, TFEB. The biology underlying tRCC development remains poorly understood, partly due to the lack of representative experimental models. Here, we utilized human kidney organoids, or tubuloid...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: f9cdbf19-eb31-513b-b12f-3127d5c959f9
DOI: 10.1101/2023.09.01.554626

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

An engineered tumor organoid model reveals cellular identity and signaling trajectories underlying translocation RCCDOI 10.1101/2023.09.01.554626Read

An engineered tumor organoid model reveals cellular identity and signaling trajectories underlying SFPQ-TFE3 driven translocation RCCSemantic proximity Read

MiTF/TFE Translocation Renal Cell Carcinomas: From Clinical Entities to Molecular InsightsSemantic proximity Read

Phenotypical screening on metastatic PRCC-TFE3 fusion translocation renal cell carcinoma organoids reveals potential therapeutic agentsSemantic proximity Read

Molecular genetics and cellular features of TFE3 and TFEB fusion kidney cancersSemantic proximity Read

Comparative genomics incorporating translocation renal cell carcinoma mouse model reveals molecular mechanisms of tumorigenesisSemantic proximity Read

TFE3 fusion proteins drive oxidative metabolism, ferroptosis resistance and general RNA synthesis in translocation renal cell carcinomaSemantic proximity Read

Chameleon TFE3-translocation RCC and How Gene Partners Can Change Morphology: Accurate Diagnosis Using Contemporary ModalitiesSemantic proximity Read

Therapeutic Targeting of TFE3/IRS-1/PI3K/mTOR Axis in Translocation Renal Cell CarcinomaSemantic proximity Read

<i>SFPQ-TFE3</i> gene fusion reciprocally regulates mTORC1 activity and induces lineage plasticity in a novel mouse model of renal tumorigenesisSemantic proximity Read

NEAT1-TFE3 and KAT6A-TFE3 renal cell carcinomas, new members of MiT family translocation renal cell carcinomaSemantic proximity Read

Incidence, clinicopathological features and fusion transcript landscape of translocation renal cell carcinomasSemantic proximity Read

Integrated exome and RNA sequencing of TFE3-translocation renal cell carcinomaSemantic proximity Read