Next-generation sequencing of translocation renal cell carcinoma reveals novel RNA splicing partners and frequent mutations of chromatin-remodeling genes.

doi:10.1158/1078-0432.CCR-13-3036

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Article

Next-generation sequencing of translocation renal cell carcinoma reveals novel RNA splicing partners and frequent mutations of chromatin-remodeling genes.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Aug 2014

Malouf Gabriel G, Su Xiaoping, Yao Hui, Gao Jianjun, Xiong Liangwen, He Qiuming, Compérat Eva, Couturier Jérôme, Molinié Vincent, Escudier Bernard, Camparo Philippe, Doss Denaha J, Thompson Erika J, Khayat David, Wood Christopher G, Yu Willie, Teh Bin T, Weinstein John, Tannir Nizar M

Abstract excerpt

PURPOSE: MITF/TFE translocation renal cell carcinoma (TRCC) is a rare subtype of kidney cancer. Its incidence and the genome-wide characterization of its genetic origin have not been fully elucidated. EXPERIMENTAL DESIGN: We performed RNA and exome sequencing on an exploratory set of TRCC (n = 7), and validated our findings using The Cancer Genome Atlas (TCGA) clear-cell RCC (ccRCC) dataset (n = 460). RESULTS:...

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Share to ATPases Associated with Diverse Cellular Activities

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Carcinoma, Renal Cell

Share to Chromatin Assembly and Disassembly

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Identifiers

PMID: 24899691
DOI: 10.1158/1078-0432.CCR-13-3036
PMCID: PMC4167829

Genes

MITF
KHDRBS2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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