Article

NDC80 status pinpoints mitotic kinase inhibitors as emerging therapeutic options in clear cell renal cell carcinoma

2023-03-10

Abstract excerpt

<h4>SUMMARY</h4> ∼30% of clear cell renal cell carcinoma (ccRCC) patients present with metastatic disease at the time of diagnosis, causing a dire 5-year survival rate of 13%. Whereas anti-PD-1 immunotherapy has improved survival, a strong need remains for new therapeutic options. Using integrated network analysis, we identified the mitotic regulator NDC80 as a predictor of ccRCC progression. Overexpression of ND...

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Literature Corpus work: e88e70f3-f250-5877-810f-2e08b1089248
DOI: 10.1101/2023.03.07.531634

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