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MiTF/TFE Translocation Renal Cell Carcinomas: From Clinical Entities to Molecular Insights

11 Jul 2022

Abstract excerpt

MiTF/TFE translocation renal cell carcinoma (tRCC) is a rare and aggressive subtype of RCC representing the most prevalent RCC in the pediatric population (up to 40%) and making up 4% of all RCCs in adults. It is characterized by translocations involving either TFE3 (TFE3-tRCC), TFEB (TFEB-tRCC) or MITF, all members of the MIT family (microphthalmia-associated transcriptional factor). TFE3-tRCC was first...

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PMID: 35886994
DOI: 10.3390/ijms23147649

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