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Article

Comprehensive molecular characterization of TFE3-rearranged renal cell carcinoma.

Experimental & molecular medicine - 1 Aug 2024

Lee Cho-Rong, Suh Jungyo, Jang Dongjun, Jin Bo-Yeong, Cho Jaeso, Lee Moses, Sim Hyungtai, Kang Minyong, Lee Jueun, Park Ju Hyun, Lee Kyoung-Hwa, Hwang Geum-Sook, Moon Kyung Chul, Song Cheryn, Ku Ja Hyeon, Kwak Cheol, Kim Hyeon Hoe, Cho Sung-Yup, Choi Murim, Jeong Chang Wook

Abstract excerpt

TFE3-rearranged renal cell cancer (tRCC) is a rare form of RCC that involves chromosomal translocation of the Xp11.2 TFE3 gene. Despite its early onset and poor prognosis, the molecular mechanisms of the pathogenesis of tRCC remain elusive. This study aimed to identify novel therapeutic targets for patients with primary and recurrent tRCC. We collected 19 TFE3-positive RCC tissues that were diagnosed by...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39085357
DOI: 10.1038/s12276-024-01291-2
PMCID: PMC11372160

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