Article

Evaluating assembly and variant calling software for strain-resolved analysis of large DNA-viruses

2020-05-16

Abstract excerpt

Infection with human cytomegalovirus (HCMV) can cause severe complications in immunocompromised individuals and congenitally infected children. Characterizing heterogeneous viral populations and their evolution by high-throughput sequencing of clinical specimens requires the accurate assembly of individual strains or sequence variants and suitable variant calling methods. However, the performance of most methods h...

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Literature Corpus work: c1452172-b25e-5f57-b684-91402e229b86
DOI: 10.1101/2020.05.14.095265

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