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Article

Evaluating assembly and variant calling software for strain-resolved analysis of large DNA viruses.

Briefings in bioinformatics - 20 May 2021

Deng Zhi-Luo, Dhingra Akshay, Fritz Adrian, Götting Jasper, Münch Philipp C, Steinbrück Lars, Schulz Thomas F, Ganzenmüller Tina, McHardy Alice C

Abstract excerpt

Infection with human cytomegalovirus (HCMV) can cause severe complications in immunocompromised individuals and congenitally infected children. Characterizing heterogeneous viral populations and their evolution by high-throughput sequencing of clinical specimens requires the accurate assembly of individual strains or sequence variants and suitable variant calling methods. However, the performance of most methods...

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PMID: 34020538
DOI: 10.1093/bib/bbaa123
PMCID: PMC8138829

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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