Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

QoALa: A comprehensive workflow for viral quasispecies diversity comparison using long-read sequencing data.

PLoS computational biology - 1 Apr 2026

Pamornchainavakul Nakarin, Schroeder Declan C, VanderWaal Kimberly

Abstract excerpt

The concept of viral quasispecies refers to a constantly mutating viral population occurring within hosts, which is essential for grasping the micro-evolutionary patterns of viruses. Despite its high error rate, long-read sequencing holds potential for advancing viral quasispecies research by resolving coverage limitations in next-generation sequencing. We introduce a refined workflow, QoALa, implemented in the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Betacoronavirus
Share to Computational Biology

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genome, Viral

Share to Quasispecies

Share to SARS-CoV-2

Share to Software

Share to Workflow

Source

Open in PubMed Open full text

Identifiers

PMID: 42048366
DOI: 10.1371/journal.pcbi.1014208
PMCID: PMC13123935

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

QoALa: A comprehensive workflow for viral quasispecies diversity comparison using long-read sequencing data.PMID 42048366Read ↗

Viral population analysis and minority-variant detection using short read next-generation sequencing.Semantic proximity Read ↗

aBayesQR: A Bayesian Method for Reconstruction of Viral Populations Characterized by Low Diversity.Semantic proximity Read ↗

Quasispecies Analyses of the HIV-1 Near-full-length Genome With Illumina MiSeqSemantic proximity Read ↗

Recent advances in inferring viral diversity from high-throughput sequencing data.Semantic proximity Read ↗

Evaluating assembly and variant calling software for strain-resolved analysis of large DNA-virusesSemantic proximity Read ↗

Easing genomic surveillance: A comprehensive performance evaluation of long-read assemblers across multi-strain mixture data of HIV-1 and Other pathogenic viruses for constructing a user-friendly bioinformatic pipelineSemantic proximity Read ↗

The effect of variant interference on de novo assembly for viral deep sequencing.Semantic proximity Read ↗

Epidemiological data analysis of viral quasispecies in the next-generation sequencing eraSemantic proximity Read ↗

De novo haplotype reconstruction in viral quasispecies using paired-end read guided path findingSemantic proximity Read ↗

Evaluation of alignment algorithms for discovery and identification of pathogens using RNA-Seq.Semantic proximity Read ↗

V-pipe 3.0: a sustainable pipeline for within-sample viral genetic diversity estimation.Semantic proximity Read ↗

Quasispecies Analysis of SARS-CoV-2 of 15 Different Lineages during the First Year of the Pandemic Prompts Scratching under the Surface of Consensus Genome SequencesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.