Article

Activation of neurogenesis improves amyloid-β pathology and cognitive function through AMP kinase signaling in Alzheimer’s disease model mice

2025-12-26

Abstract excerpt

Adult hippocampal neurogenesis declines with aging and in neurological disorders, leading to cognitive impairment. We previously demonstrated that a treatment of inducing Plagl2 , a zinc finger transcription factor gene, and antagonizing Dyrk1a , a gene associated with Down syndrome, referred to as iPaD, can functionally rejuvenate aged neural stem cells (NSCs), thereby enhancing neurogenesis and improving cogni...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: c130509b-9069-5768-80be-3439421082dd
DOI: 10.64898/2025.12.24.696442

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Activation of neurogenesis improves amyloid-β pathology and cognitive function through AMP kinase signaling in Alzheimer’s disease model miceDOI 10.64898/2025.12.24.696442Read

Proinflammatory transcriptomic and kinomic alterations in astrocytes derived from patients with familial Alzheimer's diseaseSemantic proximity Read

Transcriptomic analysis reveals new reparative mechanisms of SCF+G-CSF-reduced neuropathology in aged APP/PS1 miceSemantic proximity Read

p75 Neurotrophin Receptor Shapes the Dynamics of Adult Hippocampal Neurogenesis in Alzheimer's DiseaseSemantic proximity Read

p75 Neurotrophin Receptor Shapes the Dynamics of Adult Hippocampal Neurogenesis in Alzheimer’s DiseaseSemantic proximity Read

Cdkn2a/p16INK4A Loss Impairs Spatial Memory in Young Adult Mice Independently of Alzheimer ’s-Associated Genetic PathwaysSemantic proximity Read

Chronic PERK induction promotes Alzheimer-like neuropathology in Down syndrome: Insights for therapeutic interventionSemantic proximity Read

HDAC inhibitor–dependent transcriptome and memory reinstatement in cognitive decline modelsSemantic proximity Read

BMP4-SMAD1/5/9-RUNX2 pathway activation inhibits neurogenesis and oligodendrogenesis in Alzheimer’s patients’ iPSCs in senescence-related conditionsSemantic proximity Read

Rheb-mTOR Activation Rescues Amyloid Beta-Induced Cognitive Impairment and Memory Function by Restoring miR-146 Activity in Glial CellsSemantic proximity Read

Amyloid Precursor Protein (APP) Regulates Gliogenesis and Neurogenesis of Human Neural Stem Cells by Several Signaling PathwaysSemantic proximity Read

Inhibiting USP16 rescues stem cell aging and memory in an Alzheimer's modelSemantic proximity Read

Inhibiting USP16 rescues stem cell aging and memory in an Alzheimer’s modelSemantic proximity Read