Article

A DNA base-specific sequence interposed between CRX and NRL contributes to RHODOPSIN expression.

2023-12-23

Abstract excerpt

The binding affinity of transcription factors (TFs) for their cognate DNA sequences controls gene expression. DNA determines the recruitment and positioning of TFs; whether it plays other roles is unknown. Here we found that the specific 22-bp sequence interposed between the CRX and NRL TFs in the proximal promoter of RHODOPSIN (RHO) largely controls the expression levels of RHO. Mutagenesis of this DNA-linker seq...

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Literature Corpus work: c117d2b7-73e9-5f4a-934c-7edead815788
DOI: 10.1101/2023.12.22.573078

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