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Article

Molecular basis of CRX/DNA recognition and stoichiometry at the Ret4 response element.

Structure (London, England : 1993) - 3 Oct 2024

Srivastava Dhiraj, Gowribidanur-Chinnaswamy Pavithra, Gaur Paras, Spies Maria, Swaroop Anand, Artemyev Nikolai O

Abstract excerpt

Two retinal transcription factors, cone-rod homeobox (CRX) and neural retina leucine zipper (NRL), cooperate functionally and physically to control photoreceptor development and homeostasis. Mutations in CRX and NRL cause severe retinal diseases. Despite the roles of NRL and CRX, insight into their functions at the molecular level is lacking. Here, we have solved the crystal structure of the CRX homeodomain in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39084215
DOI: 10.1016/j.str.2024.07.004
PMCID: PMC11455607

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Molecular basis of CRX/DNA recognition and stoichiometry at the Ret4 response element.PMID 39084215Read ↗

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