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Article

A massively parallel reporter assay reveals context-dependent activity of homeodomain binding sites in vivo.

Genome research - 1 Oct 2018

Hughes Andrew E O, Myers Connie A, Corbo Joseph C

Abstract excerpt

Cone-rod homeobox (CRX) is a paired-like homeodomain transcription factor (TF) and a master regulator of photoreceptor development in vertebrates. The in vitro DNA binding preferences of CRX have been described in detail, but the degree to which in vitro binding affinity is correlated with in vivo enhancer activity is not known. In addition, paired-class homeodomain TFs can bind DNA cooperatively as both...

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Share to Binding Sites
Share to Enhancer Elements, Genetic
Share to Homeodomain Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Promoter Regions, Genetic

Share to Protein Binding

Share to Protein Multimerization

Share to Regulatory Sequences, Nucleic Acid

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Source

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Identifiers

PMID: 30158147
DOI: 10.1101/gr.231886.117
PMCID: PMC6169884

Genes

CRX

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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