Article
Targeting and silencing of rhodopsin by ectopic expression of the transcription factor KLF15.
JCI insight - 21 Dec 2017
Botta Salvatore, de Prisco Nicola, Marrocco Elena, Renda Mario, Sofia Martina, Curion Fabiola, Bacci Maria Laura, Ventrella Domenico, Wilson Cathal, Gesualdo Carlo, Rossi Settimio, Simonelli Francesca, Surace Enrico Maria
Abstract excerpt
The genome-wide activity of transcription factors (TFs) on multiple regulatory elements precludes their use as gene-specific regulators. Here we show that ectopic expression of a TF in a cell-specific context can be used to silence the expression of a specific gene as a therapeutic approach to regulate gene expression in human disease. We selected the TF Krüppel-like factor 15 (KLF15) based on its putative...
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