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Article

Complex effects of nucleotide variants in a mammalian cis-regulatory element.

Proceedings of the National Academy of Sciences of the United States of America - 20 Nov 2012

Kwasnieski Jamie C, Mogno Ilaria, Myers Connie A, Corbo Joseph C, Cohen Barak A

Abstract excerpt

Cis-regulatory elements (CREs) control gene expression by recruiting transcription factors (TFs) and other DNA binding proteins. We aim to understand how individual nucleotides contribute to the function of CREs. Here we introduce CRE analysis by sequencing (CRE-seq), a high-throughput method for producing and testing large numbers of reporter genes in mammalian cells. We used CRE-seq to assay >1,000 single and...

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Identifiers

PMID: 23129659
DOI: 10.1073/pnas.1210678109
PMCID: PMC3511131

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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