Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Functional analysis of the rod photoreceptor cGMP phosphodiesterase alpha-subunit gene promoter: Nrl and Crx are required for full transcriptional activity.

The Journal of biological chemistry - 7 May 2004

Pittler Steven J, Zhang Youwen, Chen Shiming, Mears Alan J, Zack Donald J, Ren Zhiyong, Swain Prabodh K, Yao Suxia, Swaroop Anand, White J Brandon

Abstract excerpt

To understand the factors controlling expression of the cGMP phosphodiesterase type 6 (PDE6) genes, we have characterized the promoter of the human PDE6A gene that encodes the catalytic alpha-subunit. In vivo DNase I hypersensitivity assays revealed two sites immediately upstream of the PDE6A core promoter region. Transient transfection assay in Y79 cells of constructs containing varying lengths of the promoter...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to 3',5'-Cyclic-GMP Phosphodiesterases
Share to Adenoviridae

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Basic-Leucine Zipper Transcription Factors

Share to beta-Galactosidase

Share to Cyclic Nucleotide Phosphodiesterases, Type 6

Share to Deoxyribonuclease I

Share to Luciferases

Share to Retinal Rod Photoreceptor Cells

Source

Identifiers

PMID: 15001570
DOI: 10.1074/jbc.M401864200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Functional analysis of the rod photoreceptor cGMP phosphodiesterase alpha-subunit gene promoter: Nrl and Crx are required for full transcriptional activity.PMID 15001570Read ↗

Functional dissection of the promoter of the interphotoreceptor retinoid-binding protein gene: the cone-rod-homeobox element is essential for photoreceptor-specific expression in vivo.Semantic proximity Read ↗

Transcriptional precision in photoreceptor development and diseases – Lessons from 25 years of CRX researchSemantic proximity Read ↗

Functional characterization of the human RPGR proximal promoter.Semantic proximity Read ↗

Functional Domains of the Cone-Rod Homeobox (CRX) Transcription FactorSemantic proximity Read ↗

Pathogenic variants in Crx have distinct cis-regulatory effects on enhancers and silencers in photoreceptorsSemantic proximity Read ↗

Enhancer transcription identifies <i>cis</i> -regulatory elements for photoreceptor cell typesSemantic proximity Read ↗

Functional analysis of cone-rod homeobox (CRX) mutations associated with retinal dystrophy.Semantic proximity Read ↗

Modeling of Epigenetic Modification-Induced Changes in CRX-dependent Genes <i>cis</i> -Regulatory ElementsSemantic proximity Read ↗

Interaction of human CRX and NRL in live HEK293T cells measured using fluorescence resonance energy transfer (FRET)Semantic proximity Read ↗

Mutations in the DNA-binding domain of NR2E3 affect in vivo dimerization and interaction with CRX.Semantic proximity Read ↗

<i>Rho</i> enhancers play unexpectedly minor roles in <i>Rhodopsin</i> transcription and rod cell integritySemantic proximity Read ↗

Nrl expression and promoter activity in developing cone photoreceptorsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.