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Article

Functional Domains of the Cone-Rod Homeobox (CRX) Transcription Factor

1 Nov 2000

Abstract excerpt

The paired-like homeodomain transcription factor CRX (cone-rod homeobox) is involved in regulating photoreceptor gene expression and rod outer segment development. Mutations in CRX have been associated with several retinal degenerative diseases. These conditions range from Leber congenital amaurosis (a severe cone and rod degeneration of childhood onset) to adult onset cone-rod dystrophy and retinitis pigmentosa...

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Share to Photoreceptor and optogenetics research
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PMID: 10984472
DOI: 10.1074/jbc.m002763200

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Functional Domains of the Cone-Rod Homeobox (CRX) Transcription FactorPMID 10984472Read ↗

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Leber congenital amaurosis caused by a homozygous mutation (R90W) in the homeodomain of the retinal transcription factor CRX: direct evidence for the involvement of CRX in the development of photoreceptor function.Semantic proximity Read ↗

Structural and functional analysis of the human Cone-rod homeobox transcription factorSemantic proximity Read ↗

Mutational scanning of <i>CRX</i> classifies clinical variants and reveals biochemical properties of the transcriptional effector domainSemantic proximity Read ↗

Molecular basis of CRX/DNA recognition and stoichiometry at the Ret4 response element.Semantic proximity Read ↗

Missense mutations in CRX homeodomain cause dominant retinopathies through two distinct mechanismsSemantic proximity Read ↗

Dominant Leber congenital amaurosis, cone-rod degeneration, and retinitis pigmentosa caused by mutant versions of the transcription factor CRX.Semantic proximity Read ↗

Functional dissection of the promoter of the interphotoreceptor retinoid-binding protein gene: the cone-rod-homeobox element is essential for photoreceptor-specific expression in vivo.Semantic proximity Read ↗

Mutations in the DNA-binding domain of NR2E3 affect in vivo dimerization and interaction with CRX.Semantic proximity Read ↗

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