Article

Metformin decreases <i>Cyp26a1</i> to prevent hepatocarcinogenesis through down- regulating CD8 <sup>+</sup> T cells

2022-04-28

Abstract excerpt

Hepatocellular carcinoma (HCC) is a highly heterogeneous cancer, which limits the selectivity of prevention and treatment. Preclinical and clinical studies suggested that in patients with diabetes, prolonged use of metformin, the AMPK activator, was associated with a reduction of HCC incidence. This association promotes us to investigate the possible functions and mechanisms of metformin in HCC without diabetes ba...

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Literature Corpus work: c1156a5b-434e-5280-abb8-ff701dfa04a3
DOI: 10.1101/2022.04.27.489721

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