Article

Loss of the lncRNA <i>SOX1-OT</i> promotes p53-dependent cell-cycle arrest in astrocytes

2026-07-03

Abstract excerpt

Long non-coding RNAs (lncRNAs) are increasingly recognized as regulators of brain cell function, but their roles in astrocyte biology and neurodegeneration remain poorly understood. Here, we identify Sox1ot/SOX1-OT as a conserved, brain-enriched lncRNA that is downregulated in Alzheimer’s disease and in reactive astrocyte states. Antisense oligonucleotide-mediated depletion of Sox1ot in astrocytes revealed a tra...

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Literature Corpus work: c1011494-2799-50e0-aa0a-761a728f76b6
DOI: 10.64898/2026.07.03.736275

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