Article

RNA decay defines the response to transcriptional perturbation in leukaemia

2022-04-08

Abstract excerpt

Therapeutic targeting of dysregulated transcriptional programs has arisen as a promising strategy for the treatment of leukaemias. The therapeutic response to small molecule inhibitors of Bromodomain-Containing Proteins (BRD), such as BRD2 and BRD4, P300/cAMP-response element binding protein (CBP) and Cyclin Dependent Kinases (CDKs), is generally attributed to the selective disruption of oncogenic gene expression...

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Literature Corpus work: c0eb7ca5-b184-5f68-b114-a94a906200e8
DOI: 10.1101/2022.04.06.487057

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