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Article

The role of mRNA decay in p53-induced gene expression.

RNA (New York, N.Y.) - 1 Dec 2011

Melanson Brian D, Bose Reetesh, Hamill Jeff D, Marcellus Kristen A, Pan Elysia F, McKay Bruce C

Abstract excerpt

The p53 tumor suppressor is a DNA-damage-responsive sequence-specific transcriptional activator. The sustained activation of the p53 response is incompatible with cell growth and viability. To circumvent this issue, a variety of negative feedback loops exist to limit the duration of p53 activation. Despite our understanding of p53 regulation, very little is known about the effect of transient p53 activation on...

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Share to Cell Line, Tumor

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Gene Expression Regulation

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Share to Transcription, Genetic

Share to Tumor Suppressor Protein p53

Source

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Identifiers

PMID: 22020975
DOI: 10.1261/rna.030122.111
PMCID: PMC3222134

Genes

CRYAB
DDB2
GDF15

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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