Article

Rapid-SL: Identification of Higher Order Synthetic Lethal Sets with an Arbitrary Cardinality

2022-02-16

Abstract excerpt

The multidrug resistance of numerous pathogenic microorganisms is a serious challenge that raises global healthcare concerns. Multi-target medications and combinatorial therapeutics are much more effective than single-target drugs due to their synergistic impact on the systematic activities of microorganisms. A synthetic lethal (SL) is a set of non-essential targets (i.e., reactions or genes) that prevent the prol...

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Literature Corpus work: c0dcce42-d4ed-5a78-a4e9-448b640387fd
DOI: 10.21203/rs.3.rs-1350850/v1

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