Article
NLR family pyrin domain containing 3 (NLRP3) and caspase 1 (CASP1) modulation by intracellular Cl- concentration.
Immunology - 1 Aug 2021
Clauzure Mariángeles, Valdivieso Ángel G, Dugour Andrea V, Mori Consuelo, Massip-Copiz María M, Aguilar María Á, Sotomayor Verónica, Asensio Cristian J A, Figueroa Juan M, Santa-Coloma Tomás A
Abstract excerpt
The impairment of the cystic fibrosis transmembrane conductance regulator (CFTR) activity induces intracellular chloride (Cl- ) accumulation. The anion Cl- , acting as a second messenger, stimulates the secretion of interleukin-1β (IL-1β), which starts an autocrine positive feedback loop. Here, we show that NLR family pyrin domain containing 3 (NLRP3) and caspase 1 (CASP1) are indirectly modulated by the...
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