Article

Multiomic Analysis Reveals an IFN-driven Cellular Landscape Effectively Targeted by Ruxolitinib in Hailey-Hailey Disease

2026-06-04

Abstract excerpt

<h4>ABSTRACT</h4> Hailey-Hailey disease (HHD) is a rare autosomal dominant genodermatosis characterized by skin blistering and erosions in intertriginous regions, frequently complicated by secondary infections leading to substantial impairment in quality of life. No targeted mechanism-based therapies are currently available. Here, we applied a multiomics approach to define the molecular and cellular landscape of...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: c0ad4235-33c5-5d0e-ada3-ce74fe127d8e
DOI: 10.64898/2026.06.01.729262

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Multiomic Analysis Reveals an IFN-driven Cellular Landscape Effectively Targeted by Ruxolitinib in Hailey-Hailey DiseaseDOI 10.64898/2026.06.01.729262Read

Single-Cell RNA Sequencing Reveals Cellular and Transcriptional Changes Associated With M1 Macrophage Polarization in Hidradenitis SuppurativaSemantic proximity Read

Deconstruction of immune-mediated skin diseases defines six inflammatory subtypes.Semantic proximity Read

Classification of skin transcriptome reveals two molecular subtypes in hidradenitis suppurativaSemantic proximity Read

Spatial transcriptomics landscape of lesions from non-communicable inflammatory skin diseasesSemantic proximity Read

Clinical and Molecular Effects of TYK2/JAK1 Inhibition in DermatomyositisSemantic proximity Read

Cellular indexing of transcriptomes and epitopes (CITE-Seq) in hidradenitis suppurativa identifies dysregulated cell types in peripheral blood and facilitates diagnosis via machine learningSemantic proximity Read

Spatial Orchestration of Skin Fibrosis by a CD8+ T cell-Myofibroblast AxisSemantic proximity Read

TYK2 Inhibition with Deucravacitinib Improves Clinical Outcomes and Resolves Interferon-Driven Inflammation in Lichen PlanopilarisSemantic proximity Read

Epidermal γδ T cells, CD8 T cells and macrophages are increased in number in alopecia areata and express BST2 as part of an interferon-driven antiviral gene signatureSemantic proximity Read

Dissecting type I and II interferon impacts on human immune cells in disease by a cell type-specific interferon response atlasSemantic proximity Read

Multi-Omics Molecular Profiling Enables Rapid Diagnosis of Erythrodermic Skin DiseasesSemantic proximity Read

Oral Baricitinib in the Treatment of Cutaneous Lichen PlanusSemantic proximity Read