Article

Clinical and Molecular Effects of TYK2/JAK1 Inhibition in Dermatomyositis

2026-06-26

Abstract excerpt

Dermatomyositis is driven by overactivation of type I and II interferons and other proinflammatory cytokines that signal via the JAK-STAT pathway. We conducted a 12-week, open-label study of brepocitinib, an oral TYK2/JAK1 inhibitor, in five adults with severe cutaneous dermatomyositis. Treatment was associated with rapid, clinically meaningful improvement in cutaneous disease activity. Single-cell and spatial tra...

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Literature Corpus work: 87076d50-5c42-506f-82a0-65203f7e6b31
DOI: 10.64898/2026.06.15.26354270

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