Article

Epidermal γδ T cells, CD8 T cells and macrophages are increased in number in alopecia areata and express BST2 as part of an interferon-driven antiviral gene signature

2025-06-28

Abstract excerpt

Alopecia areata is an autoimmune disorder affecting approximately 2% of the global population, characterized by immune-mediated disruption of hair follicle immune privilege and unpredictable hair loss. While CD4 and CD8 T cells are established drivers of pathogenesis, the roles of other immune cell populations remain incompletely defined. Here, we reaffirm the pathogenic role of CD8 T cells and identify a contribu...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 146b759a-a5de-501c-a6e4-e1a44a068cfc
DOI: 10.1101/2025.06.26.661822

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Epidermal γδ T cells, CD8 T cells and macrophages are increased in number in alopecia areata and express BST2 as part of an interferon-driven antiviral gene signatureDOI 10.1101/2025.06.26.661822Read

Integrated single-cell chromatin and transcriptomic analyses of peripheral immune cells in patients with alopecia areataSemantic proximity Read

A transcriptomic map of murine and human alopecia areataSemantic proximity Read

A scRNA-seq atlas of chronic inflammatory skin diseasesSemantic proximity Read

Stratification of alopecia areata reveals involvement of CD4 T cell populations and altered faecal microbiotaSemantic proximity Read

High-throughput T cell receptor sequencing identifies clonally expanded CD8+ T cell populations in alopecia areataSemantic proximity Read

Deciphering the Complex Immunopathogenesis of Alopecia AreataSemantic proximity Read

Molecular signatures define alopecia areata subtypes and transcriptional biomarkersSemantic proximity Read

Genome-wide association study in alopecia areata implicates both innate and adaptive immunity.Semantic proximity Read

Deconstruction of immune-mediated skin diseases defines six inflammatory subtypes.Semantic proximity Read

Clinical and Genetic Aspects of Alopecia Areata: A Cutting Edge Review.Semantic proximity Read

Circulating MicroRNA Signatures in Severe Alopecia Areata: Diagnostic Discrimination, Pathway Analysis, and Therapeutic ImplicationsSemantic proximity Read

Exomic sequencing of immune-related genes reveals novel candidate variants associated with alopecia universalis.Semantic proximity Read