Article

TM6SF2 binds cholesterol, interacts with apolipoprotein B, and promotes hepatic lipid secretion

2026-08-18

Abstract excerpt

A missense variant in TM6SF2 (transmembrane 6 superfamily member 2, TM6SF2 E167K ) is a major risk factor for steatotic liver disease 1 , while protecting against coronary artery disease 2 . TM6SF2 is a polytopic resident protein of the smooth endoplasmic reticulum (ER) and ER-Golgi intermediate compartment that promotes lipidation of hepatic ApoB-containing lipoproteins before secretion into the circulation. H...

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Literature Corpus work: c0ac6030-bdec-5fa4-bbdf-032680d67013
DOI: 10.64898/2026.08.17.745233

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