Article

Perturbation of transmembrane 6 superfamily member 2 expression alters lipid metabolism in a human liver cell line

2021-08-04

Abstract excerpt

<h4>Background</h4> Nonalcoholic fatty liver disease (NAFLD) is caused by accumulation of excess lipids in hepatocytes. Genome wide association studies have identified strong association of NAFLD with non-synonymous E167K amino acid mutation in transmembrane 6 superfamily member 2 (TM6SF2) protein. The E167K mutation affects TM6SF2 stability and its carriers display increased hepatic lipids levels and lower serum...

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Literature Corpus work: 1936c4b5-1e66-5df8-8132-e0969855773a
DOI: 10.1101/2021.08.04.455062

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