Article
Hepatic Tm6sf2 overexpression affects cellular ApoB-trafficking, plasma lipid levels, hepatic steatosis and atherosclerosis.
Human molecular genetics - 15 Jul 2017
Ehrhardt Nicole, Doche Michael E, Chen Shuang, Mao Hui Z, Walsh Meghan T, Bedoya Candy, Guindi Maha, Xiong Weidong, Ignatius Irudayam Joseph, Iqbal Jahangir, Fuchs Sebastien, French Samuel W, Mahmood Hussain M, Arditi Moshe, Arumugaswami Vaithilingaraja, Péterfy Miklós
Abstract excerpt
The human transmembrane 6 superfamily member 2 (TM6SF2) gene has been implicated in plasma lipoprotein metabolism, alcoholic and non-alcoholic fatty liver disease and myocardial infarction in multiple genome-wide association studies. To investigate the role of Tm6sf2 in metabolic homeostasis, we generated mice with elevated expression using adeno-associated virus (AAV)-mediated gene delivery. Hepatic...
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