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TM6SF2: A Novel Genetic Player in Nonalcoholic Fatty Liver and Cardiovascular Disease

16 Sept 2021

Abstract excerpt

Transmembrane 6 superfamily member 2 (TM6SF2) is located on chromosome 19 (19p12) and encodes for a protein of undetermined function. Genetic studies have reported the association between a nonsynonymous variant in TM6SF2 (E167K, rs58542926) with hepatic triglyceride content and its impact on the cardiovascular system. Clinical and epidemiological studies have confirmed the role of TM6SF2 in the development of...

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PMID: 34532996
DOI: 10.1002/hep4.1822

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TM6SF2: A Novel Genetic Player in Nonalcoholic Fatty Liver and Cardiovascular DiseasePMID 34532996Read ↗

Research progress on the relationship between TM6SF2 rs58542926 polymorphism and non-alcoholic fatty liver disease.Semantic proximity Read ↗

[Research progress of single-nucleotide polymorphism in theTM6SF2 rs58542926].Semantic proximity Read ↗

Exome-wide association study identifies a TM6SF2 variant that confers susceptibility to nonalcoholic fatty liver disease.Semantic proximity Read ↗

The Role of TM6SF2 in Non-Alcoholic Fatty Liver Disease: From Mechanisms To Therapeutic StrategySemantic proximity Read ↗

The dual and opposite role of the TM6SF2‐rs58542926 variant in protecting against cardiovascular disease and conferring risk for nonalcoholic fatty liver: A meta‐analysisSemantic proximity Read ↗

Perturbation of TM6SF2 Expression Alters Lipid Metabolism in a Human Liver Cell Line.Semantic proximity Read ↗

Perturbation of transmembrane 6 superfamily member 2 expression alters lipid metabolism in a human liver cell lineSemantic proximity Read ↗

TM6SF2 rs58542926 is related to hepatic steatosis, fibrosis and serum lipids both in adults and children: A meta-analysis.Semantic proximity Read ↗

The effect of the TM6SF2 E167K variant on liver steatosis and fibrosis in patients with chronic hepatitis C: a meta-analysis.Semantic proximity Read ↗

Diverse impacts of the rs58542926 E167K variant in TM6SF2 on viral and metabolic liver disease phenotypes.Semantic proximity Read ↗

Hepatic Transmembrane 6 Superfamily Member 2 Regulates Cholesterol Metabolism in Mice.Semantic proximity Read ↗

TM6SF2 rs58542926 influences hepatic fibrosis progression in patients with non-alcoholic fatty liver disease.Semantic proximity Read ↗

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