Hepatic Transmembrane 6 Superfamily Member 2 Regulates Cholesterol Metabolism in Mice.

doi:10.1053/j.gastro.2016.01.005

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Hepatic Transmembrane 6 Superfamily Member 2 Regulates Cholesterol Metabolism in Mice.

Gastroenterology - 1 May 2016

Fan Yanbo, Lu Haocheng, Guo Yanhong, Zhu Tianqing, Garcia-Barrio Minerva T, Jiang Zhisheng, Willer Cristen J, Zhang Jifeng, Chen Y Eugene

Abstract excerpt

BACKGROUND & AIMS: The rs58542926 C>T variant of the transmembrane 6 superfamily member 2 gene (TM6SF2), encoding an E167K amino acid substitution, has been correlated with reduced total cholesterol (TC) and cardiovascular disease. However, little is known about the role of TM6SF2 in metabolism. We investigated the long-term effects of altered TM6SF2 levels in cholesterol metabolism. METHODS: C57BL/6 mice...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Biomarkers

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cholesterol

Share to Cholesterol, HDL

Share to Cholesterol, LDL

Share to Diet, High-Fat

Share to Liver

Share to Transfection

Share to Triglycerides

Source

Open in PubMed Open full text

Identifiers

PMID: 26774178
DOI: 10.1053/j.gastro.2016.01.005
PMCID: PMC4842105

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Hepatic Transmembrane 6 Superfamily Member 2 Regulates Cholesterol Metabolism in Mice.PMID 26774178Read ↗

Hepatic Tm6sf2 overexpression affects cellular ApoB-trafficking, plasma lipid levels, hepatic steatosis and atherosclerosis.Semantic proximity Read ↗

Perturbation of transmembrane 6 superfamily member 2 expression alters lipid metabolism in a human liver cell lineSemantic proximity Read ↗

TM6SF2: A Novel Genetic Player in Nonalcoholic Fatty Liver and Cardiovascular DiseaseSemantic proximity Read ↗

Perturbation of TM6SF2 Expression Alters Lipid Metabolism in a Human Liver Cell Line.Semantic proximity Read ↗

The effect of the TM6SF2 E167K variant on liver steatosis and fibrosis in patients with chronic hepatitis C: a meta-analysis.Semantic proximity Read ↗

Diverse impacts of the rs58542926 E167K variant in TM6SF2 on viral and metabolic liver disease phenotypes.Semantic proximity Read ↗

TM6SF2 is a regulator of liver fat metabolism influencing triglyceride secretion and hepatic lipid droplet content.Semantic proximity Read ↗

The roles of transmembrane 6 superfamily member 2 rs58542926 polymorphism in chronic liver disease: A meta‐analysis of 24,147 subjectsSemantic proximity Read ↗

TM6SF2 binds cholesterol, interacts with apolipoprotein B, and promotes hepatic lipid secretionSemantic proximity Read ↗

TM6SF2 rs58542926 impacts lipid processing in liver and small intestine.Semantic proximity Read ↗

Human Induced Pluripotent Stem Cell based Hepatic-Modeling of Lipid metabolism associated TM6SF2 E167K variantSemantic proximity Read ↗

The Role of TM6SF2 in Non-Alcoholic Fatty Liver Disease: From Mechanisms To Therapeutic StrategySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.