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Article

Disruption of the ERLIN-TM6SF2-APOB complex destabilizes APOB and contributes to non-alcoholic fatty liver disease.

PLoS genetics - 1 Aug 2020

Li Bo-Tao, Sun Ming, Li Yun-Feng, Wang Ju-Qiong, Zhou Zi-Mu, Song Bao-Liang, Luo Jie

Abstract excerpt

Non-alcoholic fatty liver disease (NAFLD) is a metabolic disorder characterized by excess lipid accumulation in the liver without significant consumption of alcohol. The transmembrane 6 superfamily member 2 (TM6SF2) E167K missense variant strongly associates with NAFLD in humans. The E167K mutation destabilizes TM6SF2, resulting in hepatic lipid accumulation and low serum lipid levels. However, the molecular...

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Identifiers

PMID: 32776921
DOI: 10.1371/journal.pgen.1008955
PMCID: PMC7462549

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Disruption of the ERLIN-TM6SF2-APOB complex destabilizes APOB and contributes to non-alcoholic fatty liver disease.PMID 32776921Read ↗

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