Antigenic analysis of the HIV-1 envelope trimer implies small differences between structural states 1 and 2

doi:10.1016/j.jbc.2022.101819

Article

Antigenic analysis of the HIV-1 envelope trimer implies small differences between structural states 1 and 2

10 Mar 2022

Abstract excerpt

The conformationally dynamic HIV-1 envelope trimer (Env) is the target of broadly neutralizing antibodies (bnAbs) that block viral entry. Single-molecule Förster resonance energy transfer (smFRET) has revealed that HIV-1 Env exists in at least three conformational states on the virion. Prior to complete host-receptor engagement (State 3), Env resides most prevalently in the smFRET-defined State 1, which is...

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