Article

RhoGEF12 regulates endosomal SORL1-retromer and its inhibition is therapeutic in human neuronal models of Alzheimer’s disease

2026-03-09

Abstract excerpt

<h4>ABSTRACT</h4> The interaction of the endosomal sorting protein SORL1 with the retromer complex at endosomal membranes controls a recycling pathway whose dysfunction is pathogenic in Alzheimer’s disease (AD) and is linked to other neurodegenerative disorders. To search for novel therapeutic targets, we hypothesize that endosomal SORL1-retromer might be regulated by SORL1’s cytoplasmic tail. We begin by complet...

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Literature Corpus work: c097803b-1803-56c5-a5a4-a8e0b16bf822
DOI: 10.64898/2026.03.06.709427

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